EVALUATION OF COAGULATION PROFILE PATIENTS WITH PULMONARY TUBERCULOSIS AND HUMAN IMMUNODEFICIENCY VIRUS IN OWO, ONDO STATE, NIGERIA

Abstract

HIV continues to be a major global public health issue, HIV infects vital cells in the human immune system, such as helper T cells (specifically CD4+T cells), macrophages, and dendritic cells. Loss of CD4 cells leads to the development of serious illnesses, or ‘opportunistic infections’. Active infection of tuberculosis (TB) occurs more often in people with HIV/AIDS as opportunistic infection. The aim of this research was to compare Prothrombin time test (PT) and Partial thromboplastin time with kaolin in HIV and Tuberculosis patients. Two hundred participants at FMC Owo were enrolled into this study. There was a significant increase (p<0.05) in the PT and PTTK of HIV positive and TB positive subjects including Co-infected HIV and TB subjects when compared with apparently healthy individuals, There was no significant difference (p>0.05) in the prothrombin time of HIV positive subjects when compared with TB positive subjects. This study revealed that HIV and TB affects haemostasis by prolongation of Prothrombin time test (PT) and Partial thromboplastin test with kaolin (PTTK). Treatment strategies targeting haemostasis and endothelial activation may be of interest for evaluation in patients with HIV, TB and HIV-tuberculosis co-infection who continue to have an unacceptably high mortality rate.